Antibodies against citrullinated proteins in relation to periodontitis with or without rheumatoid arthritis: a cross-sectional study

Abstract Background Previous studies have reported conflicting findings between serum anti-citrullinated protein antibodies (ACPA) levels in rheumatoid arthritis (RA) participants with and without periodontitis (Pd). This study aimed to analyse possible correlations ACPA clinical parameters Pd RA participants. Methods Full mouth periodontal examination (probing pocket depth, attachment levels, gingival bleeding index, visual plaque index) was conducted samples obtained from 80 comprising RA, Pd, both (RAPd) healthy individuals (HC). Erythrocyte sedimentation rates (ESR) inflamed surface area (PISA) were obtained. Serum analysed for quantification using enzyme-linked immunosorbent assay (ELISA). Results Median (IU/mL) of (interquartile range, IQR) RAPd, HC groups 118.58(274.51), 102.02(252.89), 78.48(132.6) 51.67(91.31) respectively. significantly higher RAPd as compared group ( p < 0.05). However, any the not correlated within respective groups. Conclusions At individual level, amount seem an increasing trend diseased condition order > HC. lack significant correlation warrants further investigate causal link such a trend. Further involving more inflammatory biomarkers might be useful establish development progression or vice versa.